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Research Projects

 

No.

Program title

Funding source

Approval No.

PI

Investigator

 
 

1

Cellular and molecular mechanism of natural anti-keratin antibody production using a transgenic mouse model

NFSC major program

30330510

Yu-Feng Liu

Wei Li,

et al.

 

2

Mechanism of vitiligo due to autoimmune response induced by oxidative stress

NFSC major program

81130032

Tian-Wen Gao

Chun-Ying Li,

et al.

 

3

Model online continuous education program

National “Tenth-five year” key research program

2001-

Tian-Wen Gao

Hai-Long Zhang,

et al.

 

4

Preparation of genetic engineered human-derived anti-keratin antibodies and the application to psoriasis treatment

National “Project 863” key research program

2003AA215092

Cheng-Xin Li

Wei Li,

et al.

 

5

Preparation of genetic engineered human-derived anti-keratin antibodies

National “Project 863” key research program

2001AA215361

Cheng-Xin Li

Gang Wang,

et al.

 

6

Highly potent anti-keratin autoantibody injection

National “Project 1035” key research program

96-901-01-38

Yu-Feng Liu

Cheng-Xin Li,

et al.

 

7

Construction of a national database of dermatology and venerology case records

Ministry of Education program

2000-

Tian-Wen Gao

Hai-Long Zhang,

et al.

 

8

Regulation of Hedgehog signaling pathway and its correlation to skin squamous cell carcinoma

New century distinguished talent support project

NCET-05-0914

Cheng-Xin Li

Hai-Yan Liu,

et al.

 

9

Source collection and relevant molecular events of familial vitiligo

Ministry of Health program

2002BA711A08

Tian-Wen Gao

Chun-Ying Li,

et al.

 

10

Transgenic animal models of natural anti-keratin autoantibodies

PLT “Tenth-five year” key program

01Z086

Yu-Feng Liu

Wei Li,

et al.

 

11

Confidential project

National special fund for new major drug design

2008-

Tian-Wen Gao

Xian-Long Qi,

et al.

 

12

Pre-clinical study of a new analgesic

National special fund for new major drug design

2011ZXJ09104-09B

Bin Liu

Ai-Dong Wen,

et al.

 

13

The apoptosis effect and molecular mechanism of anti-keratin autoantibody to keratinocytes

Natural Science Foundation of China

39670675

Yu-Feng Liu

Xiao-Dong Zhao,

et al.

 

14

Cloning of cancer-related antigens identified by IgG antibody in human

Natural Science Foundation of China

39170710

Tian-Wen Gao

Da-Xiang Cui,

et al.

 

16

Gene therapy using keratinocytes as the target cell

Natural Science Foundation of China

39570656

Wen-Jun Liao

Tai-Shan Zhang,

et al.

 

17

Identification of cancer-related antigen epitopes identified by human IgG antibody

Natural Science Foundation of China

39740019

Tian-Wen Gao

Han-Cheng Li,0

 

et al.

 

18

Clonal selection and tolerance of keratin-autoreactive B cells

Natural Science Foundation of China

30300318

Wei Li

Meng Fu,

et al.

 

19

Therapeutic engineered antibodies based on key BP auto-antigen epitomes

Natural Science Foundation of China

30972805

Gang Wang

Xiao-Wei Shi,

et al.

 

20

The regulation and molecular mechanism of anti-keratin genetic engineered antibody to KC proliferation and differentiation

Natural Science Foundation of China

30000148

Cheng-Xin Li

Yu-Feng Liu,

et al.

 

21

The role and mechanism of natural antibody 3B4 in anti C. albicans infection

Natural Science Foundation of China

30972641

Yu-Feng Liu

Wei Li,

et al.

 

22

Identification of the pathogen in a new disease FBGT

Natural Science Foundation of China

30271196

Tian-Wen Gao

Xian-Long Qi,

et al.

 

23

HPV16 E6 eliminating the formation of polyploidy induced by checkpoint after mitosis

Natural Science Foundation of China

30572112

Xue-Li Fan

Zhu Shen,

et al.

 

24

Inter-upregulation of HPSE-1 and growth factor signaling pathway: a new mechanism of malignant melanoma progression

Natural Science Foundation of China

30901296

Qi Luan

Xiu-Li Yi,

et al.

 

25

Phagocytosis and mechanism of B-1 cells

Natural Science Foundation of China

30872299

Yu-Feng Liu

Wei Li,

et al.

 

26

Molecular mechanism of Hedgehog signaling pathway regulating the proliferation and apoptosis of keratinocytes

Natural Science Foundation of China

30872264

Cheng-Xin Li

Hai-Yan Liu,

et al.

 

27

Interaction and mechanism of BCR/Notch signaling pathway in the development of marginal zone B cells

Natural Science Foundation of China

30771949

Wei Li

Ji-Xin Gao,

et al.

 

28

The new mechanism of malignant melanoma invasion and metastasis

Natural Science Foundation of China

81072235

Wen-Jun Liao

Yu-Rong Xu,

et al.

 

29

The role of GSK3β in the proliferation and transfer of keratinocytes in HPV infection

Natural Science Foundation of China

81071305

Cui-Ling Ma

Yang-Yang,

et al.

 

30

The mechanism of encephalic involvement of FBGT pathogen through blood-brain barrier

Natural Science Foundation of China

31000073

Xian-Long Qi

Xue-Tao Lu,

et al.

 

31

The role and mechanism of BCR specificity and signal intensity in the development of B10 cells

Natural Science Foundation of China

31077093

Wei Li

Ji-Gang Zhang,

et al.

 

32

The influence of EGFR 3'-UTR 774T>C mutation to post-transcription of TYRP1 gene and its risk of vitiligo development

Natural Science Foundation of China

81001277

Lei Wang

Xia-Li,

et al.

 

33

Mechanism of melanocytic immunogenicity alternation due to the extra-membrane congregation of CRT/ERp57 induced by oxidative stress

Natural Science Foundation of China

81000701

Ling Liu

Ya-Jun Zhang,

et al.

 

34

Remodeling of P. acnes biological membrane, the pathogenic bacteria of FBGT, and it interaction with micro environment pH

Natural Science Foundation of China

30670117

Xian-Long Qi

Jian Gao,

et al.

 

35

Optimized design of “apoptosis simulating” immunosuppressant and the application to occasional allergic contact dermatitis treatment and prevention

Natural Science Foundation of China

30600492

Meng Fu

Yang Gao,

et al.

 

36

Identification of a newly found vitiligo-related melanocytic antigen gene sequence

Natural Science Foundation of China

30600537

Qiang Li

Ya-Jie Lv,

et al.

 

37

The role of Hedgehog signaling pathway in the pathogenesis and treatment of squamous cell carcinoma

Natural Science Foundation of China

30572099

Cheng-Xin Li

Ying Liu,

et al.

 

38

The influence of MiR-196a-2T>C mutation to TYRP1 gene regulation and the risk of vitiligo development

Natural Science Foundation of China

30972528

Chun-Ying Li

Ye Huang,

et al.

 

39

Keratin-17: a new drug target in vitiligo treatment

Natural Science Foundation of China

30371650

Gang Wang

Lin-Chao Sun,

et al.

 

41

Cloning and features of melanocytic membrane antigen autoantibody in vitiligo

Natural Science Foundation of China

30300307

Chun-Ying Li

Ling Liu,

et al.

 

42

Establishment of a new anti-oxidative stress signaling pathway ATM/Nrf2/ARE and its role in vitiligo development

Natural Science Foundation of China

30972642

Tian-Wen Gao

Kai Li,

et al.

 

43

The mechanism of gp350 related peptide fragment cloning expression and regulation to natural autoantibody production

Natural Science Foundation of China

30170862

Yu-Feng Liu

Yan-Guo Zhang,

et al.

 

44

The protective mechanism of baicalein to oxidative stress in melanocytes using Nrf2/ARE pathway

Natural Science Foundation of China

81102669

Bang-Min Liu

Bang-Min Liu,

et al.

 

45

The mechanism of Mir-155 participating in the regulation of NKT activity in vitiligo

Natural Science Foundation of China

81101189

Kai Li

Xia Li,

et al.

 

46

Screening of MicroRNA potential markers in the serum of vitiligo patients its mechanism of regulation

Natural Science Foundation of China

81172749

Chun-Ying Li

Qiong Shi,

et al.

 

47

The regulation of interleukin-17 to keratin-17 and its implication for psoriasis

Natural Science Foundation of China

81171494

Gang Wang

Liang Jin,

et al.

 

48

Pre-clinical study of a new analgesic: Fantongding capsule

Natural Science Foundation of China

2010ZDKG-108

Bin Liu

Ai-Dong Wen,

et al.

 

49

The role and mechanism of transcription factor CUTL1 in the development of malignant melanoma

Natural Science Foundation of China

30910785

Bin Liu

Qi Luan,

et al.